منابع مشابه
Activation-independent platelet adhesion and aggregation under elevated shear stress.
Platelet aggregation, which contributes to bleeding arrest and also to thrombovascular disorders, is thought to initiate after signaling-induced activation. We found that this paradigm does not apply under blood flow conditions comparable to those existing in stenotic coronary arteries. Platelets interacting with immobilized von Willebrand factor (VWF) aggregate independently of activation when...
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L ining the innermost layer of blood vessels, the endothelium is in direct contact with circulating blood elements and, consequently, is affected by mechanical forces generated by blood flow. Among these forces, fluid shear stress site-specifically regulates endothelial cells (ECs): In regions where the flowing blood is multidirectional (low shear stress or disturbed flow), ECs are activated an...
متن کاملMathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress
Increased shear stress such as observed at local stenosis may cause drastic changes in the permeability of the vessel wall to procoagulants and thus initiate intravascular blood coagulation. In this paper we suggest a mathematical model to investigate how shear stress-induced permeability influences the thrombogenic potential of atherosclerotic plaques. Numerical analysis of the model reveals t...
متن کاملThe microchannel flow model under shear stress and higher frequencies.
The microchannel flow model provides a framework for considering the effect of the vascular bed on the time domain and frequency domain response of soft tissues. The derivation originates with a single small fluid-filled vessel in an elastic medium under uniaxial compression. A fractal branching vasculature is also assumed to be present in the tissue under consideration. This note considers two...
متن کاملLocal stress relaxation and shear banding in a dry foam under shear.
We have developed a realistic simulation of 2D dry foams under quasistatic shear. After a short transient, a shear-banding instability is observed. These results are compared with measurements obtained on real 2D (confined) foams. The numerical model allows us to exhibit the mechanical response of the material to a single plastication event. From the analysis of this elastic propagator, we prop...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1716iti5